OPPORTUNITIES AND LIMITS OF THE ONE GENE APPROACH: THE ABILITY OF ATOH1 TO DIFFERENTIATE AND MAINTAIN HAIR CELLS DEPENDS ON THE MOLECULAR CONTEXT.

Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context.

Atoh1 (Math1) was the first gene discovered in ear development that showed no hair cell (HC) differentiation when absent and could induce HC differentiation when misexpressed.These data implied that Atoh1 was both necessary and sufficient for hair cell development.However, other gene mutations also result in loss of initially forming HCs, notably n

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Batch-produced, GIS-informed range maps for birds based on provenanced, crowd-sourced data inform conservation assessments.

Accurate maps of species ranges are essential to inform conservation, but time-consuming to produce and update.Given the pace of change of knowledge about species distributions and shifts in ranges under climate change and land use, a need exists for timely mapping approaches that enable batch processing employing widely available data.We develop a

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